Transcriptomes of SARS-CoV-2 naïve and recovered individuals vaccinated with inactivated vaccine. Transcriptomes of SARS-CoV-2 naïve and recovered individuals vaccinated with inactivated vaccine

The urgent approval of the use of the inactivated COVID-19 vaccine is essential to reduce the threat and burden of the epidemic on global public health, however, our current understanding of the host immune response to inactivated vaccine remains limited. We performed transcriptomics analysis on 20 SARS-CoV-2 naïve individuals who received multiple doses of inactivated vaccine and five SARS-CoV-2 recovered individuals who received single dose of inactivated vaccine. These data help us understand the reaction mechanism of the host's molecular immune system to the inactivated vaccine, and provide a basis for the choice of vaccination strategy. Overall design: Retinal mRNA profiles of 20 SARS-CoV-2 naïve individuals who received multiple doses of inactivated vaccine and five SARS-CoV-2 recovered individuals who received single dose of inactivated vaccine after 14 days.

紧急获批使用新冠病毒灭活疫苗（inactivated COVID-19 vaccine），对于减轻全球公共卫生领域的疫情威胁与防控负担至关重要，但目前学界对于宿主针对灭活疫苗的免疫应答机制的认知仍较为有限。我们对20名接种多剂次新冠病毒灭活疫苗的新冠病毒（SARS-CoV-2）未感染个体，以及5名接种单剂次新冠病毒灭活疫苗的新冠病毒感染康复个体开展了转录组学分析（transcriptomics analysis）。本数据集有助于阐明宿主分子免疫系统针对灭活疫苗的应答机制，同时可为疫苗接种策略的优化选择提供科学依据。研究设计：采集20名接种多剂次新冠病毒灭活疫苗的新冠病毒未感染个体、以及5名接种单剂次新冠病毒灭活疫苗的新冠病毒感染康复个体在接种后14天的视网膜mRNA转录组谱数据。