Supplementary file 1_Comparative efficacy and safety of acupuncture for adolescent depression: protocol for a systematic review and Bayesian network meta-analysis.docx

BackgroundAdolescents are in a critical stage of development and represent a high-risk population for depression. Various studies have demonstrated the efficacy of acupuncture therapies in the treatment of adolescent depression. However, trials directly comparing the efficacy and safety of different acupuncture therapies for adolescent depression are still lacking. To identify the optimal acupuncture therapy for treating adolescent depression, we will conduct a systematic review and network meta-analysis of various acupuncture therapies for adolescent depression.
MethodsRandomized controlled trials (RCTs) investigating the efficacy and safety of acupuncture in adolescent depression will be systematically searched across the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Web of Science, and the China National Knowledge Infrastructure (CNKI) databases from inception to December 2025. Study quality will be assessed using the Cochrane Risk of Bias Tool (RoB 2.0), while the Confidence in Network Meta-Analysis (CINeMA) framework will evaluate evidence certainty. The primary outcomes will be included at least one validated depression rating scale for adolescent. Secondary endpoints include safety outcomes, measured by the incidence of adverse events during the study period. Bayesian network meta-analysis will be performed using the gemtc package (v0.8-7) in R statistical software (version 4.0.5).
DiscussionThis study will clarify the comparative efficacy and safety of acupuncture for adolescent depression, guiding clinical decision-making.
Prospero Registration Numberidentifier (CRD 42024581768).

背景 青少年处于发育关键阶段，是抑郁症的高危人群。多项研究已证实针灸疗法对青少年抑郁症具有治疗功效，但目前仍缺乏直接比较不同针灸疗法治疗青少年抑郁症的疗效与安全性的临床试验。为明确治疗青少年抑郁症的最优针灸方案，本研究将针对各类针灸疗法治疗青少年抑郁症开展系统评价（systematic review）与网状Meta分析（network meta-analysis）。
方法 本研究将系统性检索科克伦对照试验中心注册库（Cochrane Central Register of Controlled Trials, CENTRAL）、PubMed、Embase、Web of Science及中国知网（China National Knowledge Infrastructure, CNKI）建库至2025年12月的相关随机对照试验（randomized controlled trial, RCT），纳入评估针灸疗法治疗青少年抑郁症的疗效与安全性的研究。采用科克伦偏倚风险评价工具（Cochrane Risk of Bias Tool, RoB 2.0）评估研究质量，运用网状Meta分析证据质量评价框架（Confidence in Network Meta-Analysis, CINeMA）评价证据确定性。主要结局指标为至少1项经过验证的青少年抑郁症评定量表得分；次要结局指标为安全性结局，以研究期间不良事件发生率进行衡量。将使用R统计软件（版本4.0.5）中的gemtc包（v0.8-7）开展贝叶斯网状Meta分析。
讨论 本研究将明确不同针灸疗法治疗青少年抑郁症的相对疗效与安全性，为临床决策提供指导。
PROSPERO注册编号：CRD 42024581768