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Background Placebo and nocebo effects significantly influence health outcomes, yet healthcare professionals receive limited training and guidance on their mechanisms and clinical application, creating a gap in education and practical understanding. Conducted within the European PANACEA Consortium, this study evaluated healthcare professionals’ knowledge, attitudes, and practices regarding placebo and nocebo effects, and assessed their needs in further education. Methods An online cross-sectional survey among a European multi-country convenience sample of healthcare professionals collected data assessing participants’ knowledge, perceptions, and experiences regarding placebo and nocebo effects; their application and ethical considerations in clinical practice; and investigated educational needs and interest in further training. Quantitative data were analyzed using descriptive statistics, and thematic analysis was applied to the free-text responses. Results Amongst 807 participants, 71.7% reported taking advantage of placebo effects in their practice, and over half of participants (55.8%) observing nocebo effects. Participants reported feeling somewhat confident (53.3%) in harnessing placebo effects with 47.5% feeling confident in preventing nocebo effects. The majority of respondents had not received formal training on placebo and nocebo effects, with most expressing an interest in further training in areas such as healthcare education, emphasizing communication skills to enhance placebo effects, and knowledge to recognize and reduce nocebo effects. Conclusions There is a significant need for more comprehensive training on placebo and nocebo effects, particularly in early health professional education. These findings informed the development of educational resources and best practice recommendations developed as part of the outcomes from the PANACEA Consortium, improving the understanding and application of these effects among healthcare professionals across Europe.背景：安慰剂效应（placebo effect）与负安慰剂效应（nocebo effect）可对健康结局产生显著影响，但目前医护人员接受的关于其作用机制与临床应用的培训与指导极为有限，导致该领域的教育与实践认知存在缺口。本研究由欧洲PANACEA联盟发起，旨在评估医护人员对安慰剂与负安慰剂效应的认知、态度与实践情况，并调研其继续教育需求。 方法：本研究采用线上横断面调查设计，面向欧洲多国的便利抽样医护人员群体收集数据，内容涵盖受试者对安慰剂与负安慰剂效应的认知、感知与实践经历、其在临床实践中的应用与伦理考量，同时调研了其教育需求与继续教育兴趣。定量数据采用描述性统计方法进行分析，自由文本回复则采用主题分析法进行处理。 结果：在807名受访者中，71.7%的人表示在临床实践中会利用安慰剂效应，超半数（55.8%）的受访者观察到过负安慰剂效应。约53.3%的受访者表示在运用安慰剂效应方面具备一定信心，47.5%的受访者则对预防负安慰剂效应抱有信心。绝大多数受访者未接受过关于安慰剂与负安慰剂效应的正规培训，且多数人表示有兴趣参与相关继续教育课程，例如聚焦于提升安慰剂效应的沟通技巧培训，以及识别并缓解负安慰剂效应的相关知识培训。 结论：当前医护人员亟需更为全面的安慰剂与负安慰剂效应相关培训，尤其应将其纳入早期医护专业教育体系。本研究结果为PANACEA联盟开发教育资源与最佳实践指南提供了依据，旨在提升全欧洲医护人员对这类效应的认知与应用水平。