Colorectal Neoplasia and Microbiota: Does Left Equal Right?

Many studies, including our own, have shown that colorectal cancer (CRC) is related to changes in the microbiome of the colon. However, there are limitations in most studies and questions remained unanswered. Some early data showing that the microbiome in the left vs right colon are different. The aim of this study is to investigate the microbiome (including bacteriome, virome, and fungome) of adenoma/CRC comparing the left (distal to splenic flexure) vs right side (proximal to splenic flexure) of the colon.包括本团队此前研究在内的多项研究均已证实，结直肠癌（colorectal cancer, CRC）与结肠微生物组（microbiome）的改变密切相关。然而，绝大多数现有研究仍存在一定局限性，诸多相关问题尚未得到解答。部分早期研究数据表明，左半结肠与右半结肠的微生物组存在显著差异。 本研究旨在探究腺瘤/结直肠癌患者的结肠微生物组（包括细菌组（bacteriome）、病毒组（virome）与真菌组（fungome）），并对比左半结肠（脾曲以远端）与右半结肠（脾曲以近端）的微生物组差异。