Dataset for Mathematical Model of in vitro Hepatocellular Cholesterol and Lipoprotein Metabolism, fig. 2

Comparison of numerical simulations conducted with the original model from [18] and with the newly developed model including PCSK9. In the latter, the concentration of PCSK9 in the extracellular space was 1012 molec./mL. The initial oscillations in mRNA and molecular levels, as well as the steady-state levels are reproduced well. The slow kinetics of VLDL and LDL extraction from the extracellular environment are also captured.

针对基于文献[18]中的原始模型，与新开发的包含前蛋白转化酶枯草溶菌素9（PCSK9）的模型所开展的数值模拟进行对比分析。在该新模型中，细胞外间隙内的PCSK9浓度为10¹² 分子/毫升。信使RNA（mRNA）与相关分子水平的初始振荡以及稳态水平均得到了良好的重现。从细胞外环境摄取极低密度脂蛋白（VLDL）与低密度脂蛋白（LDL）的缓慢动力学过程也被准确捕捉。