Affymetrix 6.0 study of sporadic motor neuron disease patients and controls.

This data was divided into three experiment sets: 1. A somatic study of sporadic motor neuron disease (SMND) brain samples that were compared to the blood from the same individual, normal control brains and disease control brans (Parkinson Disease patients); 2. A twin study comparing blood and other tissue samples from twins that were discordant for MND, concordant for MND and control twins and 3. A trio study of blood samples MND patients compared to their unaffected parents. Study 1: 36 sporadic motor neuron disease brain (lateral frontal cortex, Brodmann area 46), 34 matched sporadic motor neuron disease blood, 26 control brain (lateral frontal cortex, Brodmann area 46), 9 Parkinson Disease brain (disease controls, lateral frontal cortex, Brodmann area 46). Study 2 and study 3: 52 twin or trio blood, 4 twin hair, 1 twin sperm. 2 replicate twin blood and 1 replicate trio blood repeated at a different time. External control blood from Coriell GM15510 and GM10851.

本数据集共分为三个实验研究组别：
1. 散发性运动神经元病（sporadic motor neuron disease, SMND）脑组织体细胞研究：将散发性运动神经元病患者脑组织样本与同一受试者的血液样本、正常对照脑组织及帕金森病患者脑组织（疾病对照）进行比对。该研究共纳入36例散发性运动神经元病患者脑组织样本（采集自外侧额叶皮层，布罗德曼46区（Brodmann area 46））、34例匹配的散发性运动神经元病患者血液样本、26例正常对照脑组织样本（采集自外侧额叶皮层，布罗德曼46区）以及9例帕金森病患者脑组织样本（疾病对照，采集自外侧额叶皮层，布罗德曼46区）。
2. 双生子研究：对比运动神经元病（motor neuron disease, MND）表型不一致、表型一致的双生子及健康对照双生子的血液与其他组织样本。
3. 核心家系研究：以运动神经元病患者的血液样本为研究对象，与其未受累父母的血液样本进行比对。

研究2与研究3共纳入52例双生子或核心家系血液样本、4例双生子毛发样本、1例双生子精子样本；另有2份重复检测的双生子血液样本及1份重复检测的核心家系血液样本，均于不同实验批次完成重复实验。外部对照血液样本取自Coriell细胞库的GM15510与GM10851细胞系。