Data_Sheet_1_Oxygen saturation before and after mechanical thrombectomy and functional outcome in patients with acute ischemic stroke.doc

Background and purposeCurrently, there is a lack of effective neuroprotective strategies to break the ceiling effect of mechanical thrombectomy (MT), and one of the most promising is normobaric oxygen treatment. However, the impact of pre- and post-MT oxygen saturation on clinical outcomes in patients with acute ischemic stroke (AIS) remains unclear. We aimed to determine the influence of preoperative and postoperative oxygen saturation on 3-month poor outcome in patients with AIS.
MethodsA total of 239 consecutive stroke patients with successful recanalization by MT between May 2017 and March 2021 were analyzed. Oxygen saturation was measured non-invasively by pulse oximetry at baseline and continually after MT. Regression analysis was used to assess the association of preoperative and postoperative oxygen saturation with a 3-month poor outcome (modified Rankin Scale score: 3–6).
ResultsDecreased preoperative oxygen saturation level was associated with an increased risk of poor outcome (odds ratio, 0.85; 95% CI, 0.73–0.98; P = 0.0293). Postoperative oxygen saturation had the opposite effect on poor outcome (odds ratio, 1.60; 95% CI, 1.13–2.27; P = 0.0088).
ConclusionPreoperative and postoperative oxygen saturation have different impacts on 3-month poor outcome in patients with AIS with successful recanalization by MT.

研究背景与目的
目前，针对打破机械取栓（mechanical thrombectomy, MT）的天花板效应，尚缺乏有效的神经保护策略，而常压氧治疗是最具前景的策略之一。然而，急性缺血性卒中（acute ischemic stroke, AIS）患者在机械取栓术前、术后的血氧饱和度对其临床结局的影响仍不明确。本研究旨在明确术前与术后血氧饱和度对急性缺血性卒中患者3个月不良预后的影响。
研究方法
本研究分析了2017年5月至2021年3月期间共239例经机械取栓成功实现血管再通的连续性卒中患者。采用脉搏血氧饱和度仪在基线状态及机械取栓术后持续无创监测血氧饱和度。通过回归分析评估术前、术后血氧饱和度与3个月不良预后（改良Rankin量表（modified Rankin Scale）评分3~6分）的相关性。
研究结果
术前血氧饱和度降低与不良预后风险升高显著相关（比值比：0.85；95%置信区间：0.73~0.98；P=0.0293）。术后血氧饱和度则对不良预后产生相反的影响（比值比：1.60；95%置信区间：1.13~2.27；P=0.0088）。
研究结论
对于经机械取栓成功实现血管再通的急性缺血性卒中患者，术前与术后血氧饱和度对其3个月不良预后的影响存在显著差异。