Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]

Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.本研究采用基于生理学的药代动力学建模（Physiologically-based pharmacokinetic modelling），确定了分别适配小鼠与大鼠的对乙酰氨基酚（APAP）给药剂量（小鼠300 mg/kg、大鼠1000 mg/kg），使二者体内N-乙酰对苯醌亚胺（NAPQI）的肝脏负荷水平保持一致，从而能够在等效化学损伤条件下开展时序性肝组织应答的比较分析。