Hepatic responses of mice and rats to equivalent acetaminophen (APAP) insult [rat]
收藏Alliance of Genome Resources2026-08-01 收录
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Physiologically-based pharmacokinetic modelling was used to identify doses of APAP (300 and 1000 mg/kg in mice and rats, respectively) yielding similar hepatic burdens of NAPQI, to enable the comparison of temporal liver tissue responses under conditions of equivalent chemical insult.
