Allostery is a widespread cause of loss-of-function variant pathogenicity - metadata

Supplemental data: Liao, X., Lehner, B. Allostery is a widespread cause of loss-of-function variant pathogenicity. Nat Commun (2026). https://doi.org/10.1038/s41467-026-74517-8 zenodo_final_jan2026.tar.gz (supplementary table 1): proteome-wide predictions of protein stability changes and corresponding ESM-1v scores for all variants.本预印本的补充数据：Liao, X. 与 Lehner, B. (2025)《变构效应是功能丧失变异致病性的普遍诱因》，发表于 bioRxiv，2025年6月。 zenodo_final_jan2026.tar.gz（补充表1）：包含全蛋白质组范围内所有变异的蛋白质稳定性变化预测结果，以及对应的ESM-1v评分。