BindingDB Entry 50017361: FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application.

Small molecule binding data for protein Activated CDC42 kinase 1, BDNF/NT-3 growth factors receptor, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Dihydrofolate reductase, Epidermal growth factor receptor, High affinity nerve growth factor receptor, NT-3 growth factor receptor, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Receptor tyrosine-protein kinase erbB-2, Receptor tyrosine-protein kinase erbB-4, Thymidylate synthase, Trifunctional purine biosynthetic protein adenosine-3, Tyrosine-protein kinase BTK, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 3, Uniprot O00329, P00374, P00533, P04626, P04629, P04818, P11802, P22102, P35916, P35968, P48736, Q00534, Q06187, Q07912, Q15303, Q16288, and Q16620

本数据集包含激活的CDC42激酶1、脑源性神经营养因子/神经营养因子3生长因子受体、细胞周期蛋白依赖性激酶4、细胞周期蛋白依赖性激酶6、二氢叶酸还原酶、表皮生长因子受体、高亲和力神经生长因子受体、神经营养因子3生长因子受体、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基δ亚型、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基γ亚型、受体酪氨酸蛋白激酶erbB-2、受体酪氨酸蛋白激酶erbB-4、胸苷酸合酶、三功能嘌呤生物合成蛋白adenosine-3、酪氨酸蛋白激酶BTK、血管内皮生长因子受体2以及血管内皮生长因子受体3的小分子结合数据，对应通用蛋白质知识库（Uniprot）编号为O00329、P00374、P00533、P04626、P04629、P04818、P11802、P22102、P35916、P35968、P48736、Q00534、Q06187、Q07912、Q15303、Q16288及Q16620