Activity of human neural crest enhancer near NARS2 in E11.5 transgenic mouse embryo – Tg(hg38_chr11:78595308-78596197::LacZ).

Tg(hg38_chr11:78595308- 78596197::LacZ) human neural crest enhancer with biased activity in the forebrain, midbrain, maxillary prominence of the 1st branchial arch, forelimb and hindlimb buds, midgut, somites, and tail mesenchyme in comparison to the activity of the equivalent chimp enhancer. LacZ signal was also consistently observed in the periocular mesenchyme, mandibular prominence of the 1st branchial arch, and 2nd branchial arch.

Tg(hg38_chr11:78595308-78596197::LacZ) 人神经嵴增强子相较于其同源黑猩猩增强子的活性，在前脑、中脑、第一鳃弓上颌突、前后肢芽、中肠、体节及尾间充质中表现出偏好性活性。同时，在眼周间充质、第一鳃弓下颌突以及第二鳃弓中也始终可检测到LacZ信号。