CuI Mediated One-Pot Cycloacetalization/Ketalization of <i>o</i>‑Carbonyl Allylbenzenes: Synthesis of Benzo­bicyclo­[3.2.1]­octane Core

CuI/DMSO-mediated intramolecular cyclo­acetalization/ketalization of o-carbonyl allylbenzenes has been achieved for constructing [6,6,5]-tricycles having a ketal motif in good yields. The expeditious one-step route provides a three C–O bond formation. The key products with the structural framework of a benzofused dioxa­bicyclo­[3.2.1]­octane core have been confirmed by X-ray crystallographic analysis. Synthesis of dihydro­isocoumarin has been studied.碘化亚铜/二甲基亚砜（DMSO）介导的邻羰基烯丙基苯分子内环缩醛化/酮缩醇化反应已成功实现，以良好收率构建出带有酮缩醇结构基元的[6,6,5]-三环骨架。该便捷一步法路线可同步形成三根碳氧键。核心产物的苯并二氧杂双环[3.2.1]辛烷母核结构，已通过X射线晶体衍射分析得到确证。本研究同时对二氢异香豆素的合成开展了相关探索。