3D cyto- and receptor architectonic map of macaque prefrontal area 9l (v1.0)

A multimodal analysis of the macaque prefrontal cortex was carried out to create a 3D atlas integrating and reconciling discrepancies between previously published maps. This project involved a quantitative and statistically testable approach to the analysis of cytoarchitecture in the macaque monkey frontal lobe, in combination with an in vitro quantitative receptor autoradiographic analysis of the regional and laminar distribution patterns of 14 different neurotransmitter receptors. The borders of the identified areas were traced onto a reference macaque monkey brain in stereotaxic space. We provide here for the first time a map of prefrontal area 9l of the macaque monkey brain integrating cyto- and receptor architectonic features in stereotaxic space. It constitutes a valuable resource for the analysis of functional experiments with non-human primates and provides crucial data for modeling approaches with realistic synaptic dynamics.

本研究通过多模态分析猕猴前额叶皮层，构建了整合既往已发表图谱并协调其间分歧的三维脑图谱（3D atlas）。本项目采用定量且可经统计学检验的研究方法，对猕猴额叶的细胞构筑学（cytoarchitecture）展开分析，并结合体外定量受体放射自显影技术，解析14种不同神经递质受体的区域与层状分布模式。我们将所识别脑区的边界描记至立体定位空间（stereotaxic space）中的标准化猕猴参考脑上。本研究首次提供了立体定位空间中整合细胞构筑与受体构筑特征的猕猴大脑前额叶9l区图谱。该图谱可为非人灵长类（non-human primates）的功能实验分析提供宝贵的研究资源，同时为基于真实突触动力学（synaptic dynamics）的建模研究提供关键数据。