Comparisons between the aggregation parameters in different populations.

The distributions of the aggregation parameter values of the analyzed
population are compared to the ones of the reference population
using statistical tests (see Methods).
+++ and −−−
indicate that the analyzed population has a distribution
significantly (p<0.001) shifted to higher or lower values
than the reference population in the statistical tests performed,
respectively. ++ and −−, idem
(p<0.01). + and −, idem
(p<0.05).
n.s., the distributions of the analyzed and reference populations are
not significantly different (p>0.05).
aThe results remain unchanged when the sequences without signal
peptides of the corresponding subcellular districts (membrane
proteins excluded) are compared with a reference database composed
of all the human non-membrane protein sequences without the
identified signal peptides.
bProteins forming amyloid fibrils and intracellular inclusions with
amyloid-like characteristics.
cThe distributions of the two populations differ significantly
although their median values are not significantly different
(significant differences in the Kolmogorov-Smirnov test and not in
the Mann-Whitney test).
dThe difference was significant in the Mann-Whitney test but not in
the Kolmogorov-Smirnov test (parameter lacking a defined
distribution).