Comparisons between the aggregation parameters in different populations.

The distributions of the aggregation parameter values of the analyzed
population are compared to the ones of the reference population
using statistical tests (see Methods).
+++ and −−−
indicate that the analyzed population has a distribution
significantly (p<0.001) shifted to higher or lower values
than the reference population in the statistical tests performed,
respectively. ++ and −−, idem
(p<0.01). + and −, idem
(p<0.05).
n.s., the distributions of the analyzed and reference populations are
not significantly different (p>0.05).
aThe results remain unchanged when the sequences without signal
peptides of the corresponding subcellular districts (membrane
proteins excluded) are compared with a reference database composed
of all the human non-membrane protein sequences without the
identified signal peptides.
bProteins forming amyloid fibrils and intracellular inclusions with
amyloid-like characteristics.
cThe distributions of the two populations differ significantly
although their median values are not significantly different
(significant differences in the Kolmogorov-Smirnov test and not in
the Mann-Whitney test).
dThe difference was significant in the Mann-Whitney test but not in
the Kolmogorov-Smirnov test (parameter lacking a defined
distribution).

本研究通过统计检验（statistical tests，详见方法部分），将分析群体的聚集参数值分布与参考群体的对应分布进行对比。
符号+++与−−−分别代表：在本次实施的统计检验中，分析群体的分布相较于参考群体，显著（p<0.001）向更高或更低数值偏移；++与−−同理（p<0.01）；+与−同理（p<0.05）。
符号n.s.则表示分析群体与参考群体的分布无显著差异（p>0.05）。

a. 当将对应亚细胞区室（subcellular districts，膜蛋白除外）不含信号肽（signal peptides）的序列，与由所有未鉴定出信号肽的人类非膜蛋白序列组成的参考数据库进行对比时，所得结果保持一致。
b. 指形成淀粉样纤维（amyloid fibrils）且带有类淀粉样特征的细胞内包涵体（intracellular inclusions）的蛋白质。
c. 尽管两个群体的中位数无显著差异，但二者的分布仍存在显著差异：科尔莫戈罗夫-斯米尔诺夫检验（Kolmogorov-Smirnov test）呈显著差异，而曼-惠特尼检验（Mann-Whitney test）无显著差异。
d. 该差异在曼-惠特尼检验（Mann-Whitney test）中显著，但在科尔莫戈罗夫-斯米尔诺夫检验（Kolmogorov-Smirnov test）中不显著（该参数缺乏明确的分布定义）。