Additional file 1 of Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach

Additional file 1. Table S1. The primer sequences for qRT-PCR analysis. Table S2. The physicochemical and drug-like properties. Table S3. Candidate compounds and potential targets in XCD. Table S4. The ALI related targets. Table S5. Network Pharmacology analysis of XCD. Table S6. Differently expressed genes were identified between the Model and XCD groups in RNA-Seq. Table S7. The Gene and FPKM values of DEGs between Model and XCD group with significantly expression. Table S8. Analysis results of 57 target genes' PPI Network. Table S9. List of the KEGG pathway of kernel genes. Table S10. GSEA details of 57 target genes enrichment in the dataset of human lung microvascular endothelial cells (HMVEC) stimulated with or without LPS for 8 hours.

附加文件1。表S1：实时荧光定量PCR（qRT-PCR）分析所用引物序列。表S2：理化性质与类药特性。表S3：XCD中候选化合物与潜在靶点。表S4：急性肺损伤（ALI）相关靶点。表S5：XCD的网络药理学分析结果。表S6：RNA测序（RNA-Seq）中模型组与XCD组间鉴定得到的差异表达基因。表S7：模型组与XCD组间显著差异表达基因（DEGs）的基因信息及FPKM值。表S8：57个靶点基因的蛋白质-蛋白质相互作用（PPI）网络分析结果。表S9：核心基因的京都基因与基因组百科全书（KEGG）通路列表。表S10：57个靶点基因在经脂多糖（LPS）刺激或未刺激8小时的人肺微血管内皮细胞（HMVEC）数据集内富集的基因集富集分析（GSEA）详细信息。