microRNA (miRNA) expression profiling of PBMCs of Parkinson's disease (PD) patients and controls. Homo sapiens

To investigate the role of miRNAs in the etiology of idiopathic PD, we conducted global miRNA expression profiling in peripheral blood mononuclear cells (PBMCs) of PD patients and controls. Overall design: Total RNA was extracted from the PBMCs of 19 PD patients and 13 controls, labeled and hybridized to Exiqon microarrays spotted with probes for 733 human miRNAs.

为探究微小RNA（miRNAs）在特发性帕金森病（idiopathic PD）病因学中的作用，我们对帕金森病（PD）患者与健康对照者的外周血单个核细胞（peripheral blood mononuclear cells, PBMCs）开展了全基因组微小RNA表达谱分析。整体实验设计：我们从19名PD患者与13名健康对照者的PBMCs中提取总RNA，经标记后与点样有733个人类微小RNA探针的Exiqon基因芯片进行杂交。