Environmental aromatic amine induces pulmonary arterial hypertension associated with estrogen signaling and Serpine1. Environmental aromatic amine induces pulmonary arterial hypertension associated with estrogen signaling and Serpine1

We examined the molecular pathways underlying the DAPM-induced pulmonary arterial hypertension in intact and ovariectomized female rats. Overall design: 11-15 week old female (intact and ovariectomized) Sprague-Dawley rats were treated with vehicle (35% ethanol) and 25mg/kg DAPM orally once weekly for 12 weeks.

本研究探究了完整雌性与去卵巢雌性大鼠中，DAPM诱导的肺动脉高压（pulmonary arterial hypertension）背后的分子通路。
实验设计概况：选取11至15周龄的完整雌性及去卵巢雌性斯普拉格-道利（Sprague-Dawley）大鼠，分别给予溶剂对照（35%乙醇）与25mg/kg剂量的DAPM灌胃处理，每周给药1次，持续12周。