Effect of nabumetone on humoral immune responses in mice

ABSTRACT Nabumetone is used to reduce the pain and inflammation in rheumatoid arthritis. In the current study, immunomodulatory effect of Nabumetone is investigated in mice. The control group was administered normal saline orally as placebo. Nabumetone was administered orally via gavage in two treatment groups at 14mg/kg.b.w. doses and 28mg/kgb.w., respectively. Haemagglutination (HA) assay, Jerne hemolytic plaque and mice lethality assays were applied. In HA assay, the titer was significantly decreased in Nabumetone treatment groups (P摘要：萘丁美酮（Nabumetone）可用于缓解类风湿关节炎所致的疼痛与炎症。本研究探究了萘丁美酮对小鼠的免疫调节作用。实验中，对照组以口服生理盐水作为安慰剂给药。两个治疗组分别经灌胃给予萘丁美酮，给药剂量依次为14mg/kg体重与28mg/kg体重。本研究采用了血凝（HA）试验、耶尼溶血空斑试验以及小鼠致死性试验。在血凝试验中，萘丁美酮各治疗组的效价均显著降低（P