Additional file 2 of Genomic and immune profiling of breast cancer brain metastases

Supplementary Material 2. Pathways of interest tested. 79 pathways of interest from Hallmark pathways, KEGG, Gene Ontology (GO), and literature were selected a priori and included pathways relevant to oxidative phosphorylation, MAPK interacting serine/threonine Kinase (MNK), cyclin dependent kinase (CDK), DNA damage repair, and immune signaling. Column names include: Pathway type, biologically-relevant pathway group name; Pathway name, unique pathway identifier; Number of genes, number of genes in pathway; Source, source of pathway.

补充材料2. 本研究测试的候选通路。本研究从Hallmark特征通路集（Hallmark pathways）、京都基因与基因组百科全书（KEGG）、基因本体（Gene Ontology，GO）及已发表文献中，预先筛选得到79个目标通路，所纳入的通路均与氧化磷酸化、丝裂原活化蛋白激酶互作丝氨酸/苏氨酸激酶（MAPK interacting serine/threonine Kinase，MNK）、细胞周期蛋白依赖性激酶（cyclin dependent kinase，CDK）、DNA损伤修复以及免疫信号传导相关。各列定义如下：通路类型（Pathway type）：具备生物学意义的通路组名称；通路名称（Pathway name）：唯一的通路标识符；基因数量（Number of genes）：通路内所含基因的数目；来源（Source）：通路的来源渠道。