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Sirtuin-1 is required for proper trophoblast differentiation and placental development

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE100279
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In this study we identified that Sirt1 is important for mouse trophoblast stem cell (TSC) differentiation. The transcriptome of wild-type and Sirt1-null TSC were analyzed to identify dysregulation of signaling pathways. In order to identify gene expression changes in TSC in the absence of Sirt1, we performed genome-wide expression profiling of Wild-type and Sirt1-null TSCs derived from a littermate pair of embryos on the 129S1/SvlmJ genetic background.
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2021-07-25
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