An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion. An overlooked subset of Cx3cr1wt/wt microglia in the Cx3cr1CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1CreER-Eyfp/wt microglia following microglial depletion

Cx3cr1CreER-Eyfp/wt mice contain a subset of microglia lacking Cre and EYFP expression. These microglial escape Cre-mediated recombination and gain a repopulation advantage following Cre-driven DTA-mediated microglial depletion. Overall design: Identify microglia do not carry genetic labels in the widely used Cx3cr1GFP/wt or Cx3cr1CreER-EYFP/wt mouse models

Cx3cr1CreER-EYFP/wt 小鼠体内存在一群不表达Cre及EYFP的小胶质细胞（microglia）。这群小胶质细胞可逃避Cre介导的重组，并在Cre驱动的白喉毒素A（DTA）介导的小胶质细胞清除后获得增殖优势。实验整体设计：在广泛使用的Cx3cr1GFP/wt及Cx3cr1CreER-EYFP/wt小鼠模型中，鉴定未携带遗传标记的小胶质细胞。