X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form alpha

X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form alpha Descriptor: (2S)-2-hydroxybutanedioic acid, 3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate, 3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate, ... Authors: Troisi, R, Sica, F. Deposit date: 2022-04-13 Release date: 2022-11-30 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (3.18 Å) Cite: A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers. Mol Ther Nucleic Acids, 30, 2022

人源α凝血酶与假环化凝血酶结合适配体（TBA-NNp/DDp）复合物的X射线晶体结构——α晶型
描述：(2S)-2-羟基丁二酸、3-[13-甲基-5,7,12,14-四(氧代)-6,13-二氮杂四环[6.6.2.0^{4,16}.0^{11,15}]十六碳-1(15),2,4(16),8,10-五烯-6-基]丙基 3-[5,7,12,14-四(氧代)-13-(3-羟丙基)-6,13-二氮杂四环[6.6.2.0^{4,16}.0^{11,15}]十六碳-1,3,8(16),9,11(15)-五烯-6-基]丙基氢磷酸酯、3-[5-[3-双(羟)膦酰氧基丙氧基]萘-1-基]氧丙基 3-(5-氧代萘-1-基)氧丙基氢磷酸酯……
作者：Troisi R、Sica F
提交日期：2022-04-13
发布日期：2022-11-30
最后修改日期：2024-11-13
检测方法：X射线衍射（分辨率3.18 Å）
引用文献：末端官能化策略揭示抗凝血酶抗凝适配体的非常规结合能力，《分子治疗-核酸》（*Mol Ther Nucleic Acids*），30卷，2022年