Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function. Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function

Deletion of Ezh2 promotes NK cell terminal differentiation and cytotoxicity with increased IFN-γ production by a potential target Pbx1. Overall design: mRNA profiles of natural killer cells from 8-week old wild type (WT) and Ezh2ΔNK mice

敲除Ezh2可通过潜在靶基因Pbx1促进自然杀伤细胞（natural killer cell，NK）的终末分化与细胞毒性，并提升其干扰素γ（Interferon-γ, IFN-γ）的产生水平。实验整体设计：对8周龄野生型（WT）小鼠与Ezh2ΔNK小鼠的自然杀伤细胞进行mRNA表达谱分析。