SLC7A4 exchanges G6P for Pi across the ER membrane

The SLC37A4 transport protein in the endoplasmic reticulum membrane mediates the exchange of cytosolic G6P (glucose-6-phosphate) and Pi (orthophosphate) from the endoplasmic reticulum lumen. Defects in this transporter are associated with glycogen storage disease type Ib (Gerin et al. 1997; Chen et al. 2008; Veiga-da-Cunha et al. 1998).

内质网膜中的SLC37A4转运蛋白介导细胞质内葡萄糖-6-磷酸（G6P）和正磷酸（Pi）与内质网腔之间的交换。该转运蛋白的缺陷与糖原贮积病Ib型（Gerin 等人，1997年；Chen 等人，2008年；Veiga-da-Cunha 等人，1998年）相关。