Estimating the sensitivity of SiteMotif for proteins sharing similarity at each level.

Level-1 constitutes those protein pairs that share high similarity at all levels i.e similar sequence, similar structure, similar binding sites and recognise the same ligand. Whereas for level-2, similarity is observed at all levels except at the sequence with an average sequence identity less than 30%. Level-3 constitutes testing the performance of our method from the known literature reports.

第一层级（Level-1）涵盖所有层级均具有高度相似性的蛋白质对（protein pairs），即序列相似、结构相似、结合位点相似且识别同一配体（ligand）。第二层级（Level-2）的蛋白质对，除序列层面的平均序列一致性（average sequence identity）低于30%外，其余所有层级均呈现相似性。第三层级（Level-3）则用于基于已公开的文献报道，检验我们方法的性能。