WES of readapted mouse cancer cells

Tumors that were in growth arrest after CD4 TCR-T cell therapy were readapated in vitro. Newly established cancer cel lines were used for whole-exome-sequencing to determine changes in mutational burden after CD4 TCR-T cell therapy.经CD4 TCR-T细胞疗法（CD4 TCR-T cell therapy）处理后处于生长停滞状态的肿瘤被体外重培养。研究人员利用新建立的癌细胞系开展全外显子测序（whole-exome-sequencing），以明确CD4 TCR-T细胞疗法干预后肿瘤突变负荷的变化情况。