Genomic Investigation of Unusual Responders

Studies have shown that tumors from the same patient may respond very differently to the same therapeutic agents. This study aims to investigate the genetic basis of tumors that respond abnormally well or poorly to therapeutic agents in an effort to understand the fundamental genetic basis of this response. The present protocol seeks to retrospectively perform Exome, next-generation (DNA) sequencing and/or other molecular techniques on tumor samples to identify the genetic basis of a patient’s exceptional response to chemotherapy.已有研究证实，同一患者体内的肿瘤对同一种治疗药物的应答可表现出显著差异。本研究旨在探究对抗肿瘤药物应答异常优异或极差的肿瘤的遗传基础，以阐明此类应答差异的核心遗传机制。本实验方案拟对肿瘤样本开展回顾性外显子组（Exome）、下一代（DNA）测序及/或其他分子生物学技术检测，以明确患者对化疗产生特殊应答的遗传基础。