Conformationally Locked Bridged Bicyclic Diselenides: Synthesis, Structure, Se···O Interaction, and Theoretical Studies

A general synthetic methodology has been developed for the synthesis of a conformationally locked,
bridged diselena-bicyclo[3.2.1]octane skeleton by regio- and stereospecific tandem nucleophilic ring
opening of cis-1,4-aziridino-epoxides with tetraethylammonium tetraselenotungstate [Et4N]2WSe4, 1, in
a one-pot synthesis. Some correlations have been made on the physicochemical characteristics of the
diselenides with a change in the dihedral angles.

本研究开发了一种通用合成方法，可通过区域及立体专一性的串联亲核开环反应，以四乙基铵四硒代钨酸盐([Et4N]2WSe4，记为试剂1）与顺式-1,4-氮丙啶基环氧化物为反应物，实现一锅法合成构象锁定的（conformationally locked）桥联二硒代双环[3.2.1]辛烷（diselena-bicyclo[3.2.1]octane）骨架。此外，本研究还针对二硒代化合物的物理化学性质随二面角的变化建立了相关关联。