Gene expression profiles of human osteosarcoma

Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatric cancer is necessary. Pet dogs naturally develop osteosarcoma providing a novel opportunity to model metastasis development and progression. Given the accelerated biology of canine osteosarcoma, we hypothesized that a direct comparison of canine and pediatric osteosarcoma expression profiles may help identify novel metastasis-associated tumor targets that have been missed through the study of the human cancer alone. Collectively, these data support the strong similarities between human and canine osteosarcoma and underline the opportunities provided by a comparative oncology approach as a means to improve our understanding of cancer biology and therapy. Profiles of human osteosarcoma and three normal tissues, single channel design肺转移仍是骨肉瘤患者最常见的死亡原因。事实上，近20余年来，新确诊骨肉瘤患者的5年生存率未出现显著改善。针对这种高侵袭性儿童恶性肿瘤，进一步阐明其转移与耐药机制实属必要。宠物犬会自然罹患骨肉瘤，为构建转移发生与进展的研究模型提供了全新契机。鉴于犬骨肉瘤的生物学行为进展更为迅速，我们推测，直接对比犬类与儿童骨肉瘤的表达谱，或可识别出仅通过人类癌症研究而被遗漏的新型转移相关肿瘤靶点。综上，本研究数据证实了人类与犬类骨肉瘤之间存在高度相似性，并凸显了比较肿瘤学研究方法在增进我们对癌症生物学与治疗认知方面的应用价值。本数据集涵盖人类骨肉瘤与三种正常组织的表达谱，采用单通道实验设计。