Transcriptional profiling of induced reprogramming trajectories. Transcriptional profiling of induced reprogramming trajectories

To elucidate the interplay between signal transduction and transcriptional regulation in cellular reprogramming, distinct induction routes from epiblast stem cells to naïve pluripotency were evaluated and compared.

为阐明细胞重编程（cellular reprogramming）过程中信号转导（signal transduction）与转录调控（transcriptional regulation）之间的相互作用，本研究对从上胚层干细胞（epiblast stem cells）向初始多能性（naïve pluripotency）转化的不同诱导路径进行了评估与比较。