3D models of NNC2215

1. Cryo-EM structure of the full-length insulin receptor bound to four insulin molecules. This experimental 3D structure has been used to dock-in the models of inactive (closed) and active (open) NNC2215. 2. 3D model of NNC2215 in an open form with a free glucose molecule bound in the macrocycle. 3. 3D model of NNC2215 in a closed form with the glucoside bound in the macrocycle. 4. 3D models (chimeraX format) of NNC2215 in open and closed forms docked into the insulin receptor (chains A and C from Protein Data Bank entry 6PXV). The open form of NNC2215 (yellow) has free glucose (orange) bound into the macrocycle at B29.

1. 结合四个胰岛素分子的全长胰岛素受体冷冻电镜（Cryo-EM）结构。该实验三维结构已被用于对接非活性（闭合态）与活性（开放态）NNC2215的模型。
2. 大环结合游离葡萄糖分子的开放态NNC2215三维模型。
3. 大环结合糖苷的闭合态NNC2215三维模型。
4. 以ChimeraX格式保存的开放态与闭合态NNC2215三维模型，该类模型被对接至取自蛋白质数据库（Protein Data Bank）条目6PXV的A链与C链的胰岛素受体。其中开放态NNC2215（黄色）的大环B29位点结合有游离葡萄糖（橙色）。