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Vitamin D plays an essential role in bone and mineral metabolism. There is increased interest in understanding prevalence of Vitamin D deficiency in pregnancy as many studies report association of low vitamin D levels with obstetric complications and neonatal sequelae. There is a paucity of studies in Singapore evaluating levels of vitamin D levels during the first trimester of pregnancies. We aim to study the prevalence of vitamin D insufficiency in this population. Our study assessed vitamin D levels in these women. Vitamin D (Plasma 25(OH)D concentration) levels in multiracial women during the first trimester were collected via venepuncture at their booking antenatal visit. They were stratified into sufficient ≥30ng/ml, insufficient ≥20ng/ml and <30ng/ml, moderately deficient ≥10ng/ml and <20ng/ml and severely deficient <10ng/ml. 93 women were included in this study. Only 2.2% of our study population had sufficient vitamin D levels. In women who had insufficient levels, the heavier the weight, the more likely to be vitamin D deficient. Interestingly, we also note that the older the patient, the less likely they are to be deficient. In women with periconceptual multivitamin supplementation, the average vitamin D level for those with supplementation was 2.10ng/ml higher than those without. Majority of patients were recruited from a single study member’s patient pool who were mostly Chinese. Prevalence of Vitamin D deficiency in general obstetric patients with higher BMI and darker skinned patients may be even lower in Singapore. The high prevalence of Vitamin D insufficiency in our patients prove that it is a prominent problem in our population. We aim to implement screening of vitamin D levels as part of antenatal investigations in the first trimester and recommend supplementation as required. We also hope to evaluate the association of low vitamin D levels with obstetric or neonatal complications further understanding its implications.维生素D（Vitamin D）在骨骼与矿物质代谢中发挥关键作用。当前学界对妊娠期维生素D缺乏的患病率研究关注度日益提升，诸多研究均指出低维生素D水平与产科并发症及新生儿后遗症存在关联。目前新加坡地区针对妊娠早期维生素D水平的相关研究较为匮乏，本研究旨在探究该人群中维生素D不足的患病率。 本研究对目标孕妇群体的维生素D水平进行了检测：研究对象为多族裔孕妇，于首次产前建档就诊时通过静脉采血获取其血浆25-羟维生素D（25(OH)D）浓度作为检测指标，并依据该浓度将受试者分为四组：维生素D充足（≥30ng/ml）、不足（20ng/ml ≤ 浓度 <30ng/ml）、中度缺乏（10ng/ml ≤ 浓度 <20ng/ml）及重度缺乏（<10ng/ml）。本研究共纳入93名受试者，仅2.2%的研究对象维生素D水平充足。 在维生素D水平不足的孕妇中，体重越大，其维生素D缺乏的可能性越高。值得注意的是，本研究同时发现孕妇年龄越大，维生素D缺乏的可能性越低。相较于未补充者，围受孕期服用复合维生素的孕妇，其平均维生素D水平高出2.10ng/ml。大部分受试者来自单名研究成员的患者队列，其中以汉族人群为主。新加坡地区普通产科患者中，高体质指数（BMI）人群与肤色较深者的维生素D缺乏患病率或许甚至更低。 本研究受试者中维生素D不足的高患病率表明，该问题在新加坡人群中十分突出。本研究计划将妊娠早期维生素D水平筛查纳入产前检查项目，并根据个体需求推荐维生素D补充剂。此外，本研究还希望进一步探究低维生素D水平与产科及新生儿并发症之间的关联，以明确其临床意义。