ACSS2 alleviates alcoholic liver disease via modulating hepcidin-mediated systemic iron homeostasis and hepatic ferroptosis

Alcoholic liver disease (ALD) is one of the most prevalent types of liver disease associated with high morbidity and mortality, caused by hepatotoxicity originating from alcohol metabolism, but current therapeutic drugs are still limited. The role of ACSS2 as an enzyme that metabolizes acetate in ALD remains unknown. Our study aimed to investigate the function of ACSS2 and its potential mechanism in ALD progression. To explore the function of ACSS2 in alcoholic liver disease, hepatocyte-specific knockout mice were generated and the liver transcriptome analysis was performed

酒精性肝病（Alcoholic liver disease, ALD）是全球高发的肝病类型之一，其由酒精代谢产生的肝毒性所引发，伴随极高的发病率与死亡率，但目前可用的治疗药物仍十分有限。ACSS2作为一种在酒精性肝病中代谢乙酸的酶，其在该病中的作用尚未明确。本研究旨在探究ACSS2在酒精性肝病进展中的功能及其潜在作用机制。为明确ACSS2在酒精性肝病中的功能，本研究构建了肝细胞特异性敲除小鼠模型，并开展了肝脏转录组分析。