Dataset of 320 novel T cell receptor (TR) alleles identified from 44 HPRC subjects

This dataset is based on high-quality genome assemblies provided by the Human Pangenome Reference Consortium (HPRC), which represent diverse human genomes to ensure comprehensive coverage of genetic diversity. Using the gAIRR Suite (https://github.com/maojanlin/gAIRRsuite), we identified 320 novel T Cell Receptor (TR) alleles from 44 HPRC assemblies. These alleles are categorized into two groups: TRV_novel.fastaContains novel T Cell Receptor Variable (TRV) alleles. TRJ_novel.fastaContains novel T Cell Receptor Joining (TRJ) alleles. Supporting Files: TRV_novel_haplotype_seq.csvProvides a summary of TRV alleles identified in HPRC subjects, including novel alleles. Each row contains the nucleotide sequence of an allele and the corresponding haplotypes (h1 for paternal and h2 for maternal).(NOTE: TRBV11-1*01_B6R4 and TRGV10*02_FO2S have not been validated.) TRJ_novel_haplotype_seq.csvProvides a summary of TRJ alleles identified in HPRC subjects, including novel alleles. Each row contains the nucleotide sequence of an allele and the corresponding haplotypes (h1 for paternal and h2 for maternal)(NOTE: TRBJ2-7*01_UZLC has not been validated.) The genome assemblies were sourced from the official HPRC GitHub repository:https://github.com/human-pangenomics/HPP_Year1_Assemblies. This dataset offers a valuable resource for studying T Cell Receptor diversity and its role in immune function.本数据集基于人类泛基因组参考联盟（Human Pangenome Reference Consortium, HPRC）提供的高质量基因组组装序列，该系列组装涵盖多样化的人类基因组，以实现对遗传多样性的全面覆盖。 本研究采用gAIRR Suite（https://github.com/maojanlin/gAIRRsuite），从44份HPRC基因组组装序列中鉴定出320个全新的T细胞受体（T Cell Receptor, TR）等位基因。这些等位基因分为两类： TRV_novel.fasta：包含全新的T细胞受体可变区（T Cell Receptor Variable, TRV）等位基因。 TRJ_novel.fasta：包含全新的T细胞受体连接区（T Cell Receptor Joining, TRJ）等位基因。 辅助文件： TRV_novel_haplotype_seq.csv：汇总了在HPRC受试者中鉴定出的TRV等位基因（包含全新等位基因）。每一行包含一个等位基因的核苷酸序列及其对应的单倍型（h1代表父本单倍型，h2代表母本单倍型）。（注：TRBV11-1*01_B6R4与TRGV10*02_FO2S尚未经过验证） TRJ_novel_haplotype_seq.csv：汇总了在HPRC受试者中鉴定出的TRJ等位基因（包含全新等位基因）。每一行包含一个等位基因的核苷酸序列及其对应的单倍型（h1代表父本单倍型，h2代表母本单倍型）。（注：TRBJ2-7*01_UZLC尚未经过验证） 本数据集所用的基因组组装序列来源于HPRC官方GitHub仓库：https://github.com/human-pangenomics/HPP_Year1_Assemblies。 本数据集为研究T细胞受体多样性及其在免疫功能中的作用提供了极具价值的研究资源。