<b>Oncogenic Human Papillomavirus and Anal Microbiota in Men Who Have Sex with Men and are Living with HIV in </b><b>Northern Taiwan </b>

This study focused on the interrelationships in human immunodeficiency virus (HIV), anal human papillomavirus (HPV), and anal microbiota. We explored in a cohort of 291 persons living with HIV (PLWH), mainly comprising men who have sex with men. We found that in PLWH with CD4+ T cells <500 cells/µL and anal cytology yielding atypical squamous cells of undetermined significance or higher grades (ASCUS+) with detectable HPV 16/18, the bacterial diversity was diminished, and Enterobacteriaceae, Ruminococcus, and Bacilli were significantly abundant. The signature microbiota profiles warrant further exploration.本研究聚焦于人类免疫缺陷病毒（human immunodeficiency virus, HIV）、肛门人乳头瘤病毒（anal human papillomavirus, HPV）与肛门微生物群之间的相互关联。我们在由291名人类免疫缺陷病毒感染者（persons living with HIV, PLWH）组成的队列中开展探索性研究，该队列主体为男男性行为者。研究发现，在CD4+ T淋巴细胞计数＜500细胞/微升、肛门细胞学检查提示非典型鳞状细胞意义不明确或更高级别病变（ASCUS+）且可检测到HPV 16/18型的PLWH群体中，细菌多样性有所降低，而肠杆菌科（Enterobacteriaceae）、瘤胃球菌属（Ruminococcus）与芽孢杆菌纲（Bacilli）的丰度显著升高。该特征性微生物群谱值得开展进一步的探索研究。