Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia

Salidroside is a key bioactive component of Rhodiola species that are widely used as traditional medicines. Among them, Rhodiola crenulata is cited as a traditional Chinese medicine to treat stroke in the Chinese Pharmacopoeia. This therapeutic action of Rhodiola crenulata may involve neurogenesis, as it is known that Rhodiola crenulate enhances hippocampal neurogenesis against streptozotocin-induced neural injury in rats, probably through protecting neural stem cells by salidroside. Salidroside has attracted considerable attentions as a potential agent for the clinic, as it exhibits neuroprotective properties across a remarkably wide time window in a variety of experimental stroke models. However, whether salidroside induces neurogenesis after cerebral ischemia and its primary molecular targets remain unknown.To explore whether salidroside induces neurogenesis after cerebral ischemia, and whether the neurogenic and neuroprotective effects of salidroside are through interaction with heat shock cognate 71-kDa protein (HSC70) as its primary molecular target.

红景天苷（Salidroside）是红景天属（Rhodiola）植物的关键活性成分，该属植物作为传统药物应用广泛。其中，大花红景天（Rhodiola crenulata）被《中华人民共和国药典》收载为治疗中风的中药材。大花红景天的该治疗作用可能与神经发生相关：已有研究证实，其可通过红景天苷保护神经干细胞，进而增强大鼠对抗链脲佐菌素（streptozotocin）诱导的神经损伤的海马神经发生能力。红景天苷作为潜在临床候选药物已受到广泛关注，因其可在多种实验性中风模型中，于极宽的时间窗口内展现出显著的神经保护特性。然而，目前仍不清楚红景天苷是否可在脑缺血后诱导神经发生，也尚未明确其首要分子靶点。本研究旨在探究红景天苷是否可在脑缺血后诱导神经发生，以及其神经发生与神经保护效应是否通过与其首要分子靶点热休克同源71kDa蛋白（heat shock cognate 71-kDa protein, HSC70）相互作用实现。