FeCl₃ Catalyzed Regioselective <i>C</i>‑Alkylation of Indolylnitroalkenes with Amino Group Substituted Arenes

An efficient FeCl3 catalyzed protocol for the synthesis of amino functionalized indolyl­nitro­alkanes from easily available precursor indolyl­nitroalkenes and substituted amines has been developed. Regioselective C-alkylation in the presence of free amino substituted arenes occurred. The scope of this methodology shows good functional group tolerance, and further, this protocol was used to prepare indolyl­quinoline derivatives.本研究开发了一种以易得的前体吲哚基硝基烯烃与取代胺为原料，三氯化铁（FeCl₃）催化的高效合成氨基官能化吲哚基硝基烷烃的方法。该反应可在含游离氨基取代芳烃的体系中实现区域选择性C-烷基化。该方法展现出良好的官能团兼容性，且可进一步用于制备吲哚基喹啉衍生物。