Mitochondrial Stress-induced H4K12 Hyperacetylation Dysregulates Transcription in Parkinson's Disease

Bulk RNA-Seq of littermate controls and Parkinson's disease (PD) transgenic mice models (n=3) The goals of this study are to compare transcriptome profiling (RNA-Seq) in the specific brain region of littermate control and our PD transgenic mice model and look for differential expression genes of interest Overall design: mRNA profiles of 16~17-week littermate controls and our PD transgenic mice

批量RNA测序（Bulk RNA-Seq）：同窝对照与帕金森病（Parkinson's disease, PD）转基因小鼠模型（样本量n=3）
本研究旨在对比同窝对照小鼠与本课题组构建的PD转基因小鼠模型特定脑区的转录组测序（RNA-Seq）谱，并鉴定目标差异表达基因。
实验设计概要：16~17周龄同窝对照小鼠与本课题组PD转基因小鼠的mRNA表达谱。