HSP90 buffers penetrance of newly induced mutations in massively mutated plant lines

Identification of candidate causal mutations via bulk segregant analysis of EMS-mutated A. thaliana that show increased incidence of aberrant phenotype when grown on HSP90-reducing agents.通过对经乙基甲磺酸（EMS）诱变的拟南芥（A. thaliana）开展混合分离分析（bulk segregant analysis），鉴定在经热休克蛋白90（HSP90）消减剂处理后异常表型发生率升高的候选致因突变。