Vastus lateralis muscle biopsy: post-expedition vs. pre-expedition. Homo sapiens

To define the skeletal muscle adaptations induced by exercise performed at high altitude hypoxia, we investigated if the gene expression profile of Vastus lateralis muscle was affected by 5000 m-above-sl-expedition. Overall design: Two-condition experiment, Vastus lateralis muscle biopsy post-expedition vs Vastus lateralis muscle biopsy pre-expedition. Five volunteers/climbers. Biological replicates: 1 pre-expedition sample, 1 post-expedition sample.

为明确高海拔低氧环境下运动所诱导的骨骼肌适应性变化，本研究探究了股外侧肌（Vastus lateralis）的基因表达谱是否受海拔5000米野外探险的影响。实验总体设计：设置双条件对照实验，对比探险后采集的股外侧肌活检样本与探险前采集的股外侧肌活检样本。共纳入5名志愿者/登山者，生物学重复设置为：每名受试者各对应1份探险前样本与1份探险后样本。