Analysis of differential genes in PA-stimulated H9c2 cells treated with dapagliflozin

The purpose of this study was to investigate the effect of dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor, on obesity-related cardiac dysfunction and its potential molecular mechanism.We utilized 3 groups of H9c2 cells, as following: 1) Con: H9c2 cells with vehicle treatment, 2) PA: H9c2 cells treated with PA, 3) PA+Dapa: H9c2 cells pretreated with Dapa and then stimulated with PA.

本研究旨在探究钠-葡萄糖协同转运蛋白2抑制剂达格列净（dapagliflozin, DAPA）对肥胖相关心功能不全的影响及其潜在分子机制。本研究共设置3组H9c2细胞，具体分组如下：1）对照组（Con）：仅经溶剂处理的H9c2细胞；2）PA处理组：经PA处理的H9c2细胞；3）PA+Dapa组：先用DAPA预处理，随后以PA刺激的H9c2细胞。