Baseline Clinical Dataset in Life After Pediatric Sepsis Evaluation

This file includes baseline clinical information Study Description The purpose of this prospective observational study was to describe short and long-term outcomes among children surviving septic shock. LAPSE investigated the intensity and duration of sepsis-associated morbidity that persists following the acute septic event. LAPSE described the post sepsis illness trajectory through Health Related Quality of Life (HRQL) and subject functional status (FS). LAPSE examined organ dysfunction, as well as individual and environmental characteristics that influenced these outcomes. We hypothesized that variation of HRQL and FS would be seen following survival of severe sepsis, enabling development of composite outcome measures for future trials of pediatric sepsis. This study found that 11% of the children died within 3 months of their septic shock episode. Additionally, duration of stay, cumulative vasoactive-inotropic scores, duration of mechanical ventilation, and other factors were associated with adverse outcomes. This study enrolled infants and children with community acquired infection and severe sepsis. Subjects were evaluated in detail to enable assessment of life quality as well as survival outcomes.本文件包含基线临床资料。 ## 研究概述 本项前瞻性观察研究旨在描述脓毒性休克存活儿童的短期与远期转归。LAPSE研究对急性脓毒症事件后持续存在的脓毒症相关并发症的严重程度与持续时长进行了考察，通过健康相关生活质量（Health Related Quality of Life, HRQL）与受试者功能状态（Functional Status, FS）刻画了脓毒症后疾病轨迹，并分析了器官功能障碍以及影响上述转归的个体与环境特征。本研究提出假设：重症脓毒症存活患儿的健康相关生活质量与功能状态存在异质性，这可为未来儿童脓毒症临床试验的复合转归指标开发提供依据。 本研究结果显示，11%的患儿在脓毒性休克发作后3个月内死亡。此外，住院时长、累积血管活性-正性肌力药物评分、机械通气时长等多种因素与不良转归相关。本研究纳入了患有社区获得性感染与重症脓毒症的婴幼儿及儿童受试者，并对受试者进行详细评估，以全面考察其生活质量与生存转归。