Copper-Catalyzed Oxidative Dearomatization/Spirocyclization of Indole-2-Carboxamides: Synthesis of 2‑Spiro-pseudoindoxyls
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https://figshare.com/articles/dataset/Copper-Catalyzed_Oxidative_Dearomatization_Spirocyclization_of_Indole-2-Carboxamides_Synthesis_of_2_Spiro-pseudoindoxyls/4232810
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资源简介：
A copper-catalyzed
oxidative dearomatization/spirocyclization of
indole-2-carboxamides using tert-butyl hydroperoxide
(TBHP) as the oxidant has been developed that provides rapid and efficient
access to C2-spiro-pseudoindoxyls. Two of the sp2 C–H
bonds are functionalized during the reaction process, and the reaction
likely proceeds via the formation of a highly reactive 3H-indol-3-one intermediate followed by aromatic electrophilic substitution
with the N-aryl ring of the amide moiety.
创建时间：
2016-11-14
