Between-study heterogeneity and random versus fixed effects calculations for polymorphisms that were considered “confirmed”

Additive models are presented, as in the main analyses of the original papers. Fixed effects calculations are Mantel-Haenszel estimates as in the original papers. Random effects calculations use the DerSimonian and Laird estimators for the between-study variance.CI: confidence interval; OR: odds ratioamulti-marker tag in DGI and rs1514823 in the UK studybrs7754840 in FUSIONcrs5219 in FUSION and DGIdrs7903146 in FUSION and DGI如原始文献的主要分析所示，本研究采用加性模型（additive models）。固定效应分析采用原始文献中的Mantel-Haenszel估计值（Mantel-Haenszel estimates）。随机效应分析针对研究间方差，采用DerSimonian-Laird估计量（DerSimonian and Laird estimators）。CI：置信区间（confidence interval）；OR：比值比（odds ratio）。 a. DGI中的多标记标签（multi-marker tag）以及英国研究中的rs1514823 b. FUSION中的rs7754840 c. FUSION与DGI中的rs5219 d. FUSION与DGI中的rs7903146