Gene summary for Pitx2

### Genome Browser Links [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=PITX2) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=PITX2) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=PITX2) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=PITX2) ### Reference Images | E12.5 | E13.5 | E14.5 | E15.5 | |-------|-------|-------|-------| |  |  |  |  | ### Gene expression in the secondary palate At E13.5, _Pitx2_ is expressed in the palatal epithelium along the AP axis. At E14.5, _Pitx2_ is expressed in both the epithelium and the osteogenic mesenchyme along the AP axis. | | E12.5 | E13.5 | E14.5 | E15.5 | |--------|-------|-------|-------|-------| | **Coronal** |  | {width=100} | {width=100} |  | | **Intraoral** |  | {width=100} | {width=100} |  | N: Nasal Pr: Proximal Di: Distal O: Oral  Osteogenic mesenchyme  All mesenchyme (AP axis)  All epithelium #### Sources: - Iwata et al. (2012) [Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor β (TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis.](http://www.ncbi.nlm.nih.gov/pubmed/22123828) J. Biol. Chem. 287(4):2353-63. ### External Links - [Pitx2 paired-like homeodomain transcription factor 2 [ Mus musculus (house mouse) ]](http://www.ncbi.nlm.nih.gov/gene/18741) - [Pitx2 paired-like homeodomain 2 [ Homo sapiens (human) ]](http://www.ncbi.nlm.nih.gov/gene/5308) - [Pitx2 genecard](http://www.genecards.org/cgi-bin/carddisp.pl?gene=PITX2&search=pitx2) - [Pitx2 Wikipedia](http://en.wikipedia.org/wiki/PITX2)

### 基因组浏览器链接 [mm9](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm9&singleSearch=knownCanonical&position=PITX2) | [mm10](http://genome.ucsc.edu/cgi-bin/hgTracks?db=mm10&singleSearch=knownCanonical&position=PITX2) | [hg18](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&singleSearch=knownCanonical&position=PITX2) | [hg19](http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&singleSearch=knownCanonical&position=PITX2) ###

### 参考图像
| E12.5 | E13.5 | E14.5 | E15.5 |
|-------|-------|-------|-------|
|  |  |  |  |

### 次生腭中的基因表达
在E13.5时，*PITX2*（成对样同源域转录因子2）沿前后轴（AP轴）表达于腭上皮中。在E14.5时，*PITX2*沿前后轴（AP轴）表达于上皮及成骨间充质中。

| | E12.5 | E13.5 | E14.5 | E15.5 |
|--------|-------|-------|-------|-------|
| **冠状面** |  | {width=100} | {width=100} |  |
| **口内视图** |  | {width=100} | {width=100} |  |

标注说明：
N：鼻区（Nasal）；Pr：近端（Proximal）；Di：远端（Distal）；O：口侧（Oral）

 成骨间充质
 前后轴（AP轴）全间充质
 全上皮

#### 数据来源
- Iwata等人（2012）发表于《Journal of Biological Chemistry》（287卷第4期，第2353-2363页）的研究：「成纤维细胞生长因子9（FGF9）-PITX2通路介导转化生长因子β（TGFβ）信号以调控小鼠腭发生过程中腭间充质的细胞增殖」，链接：http://www.ncbi.nlm.nih.gov/pubmed/22123828

### 外部链接
- [小鼠（*Mus musculus*）PITX2基因：成对样同源域转录因子2](http://www.ncbi.nlm.nih.gov/gene/18741)
- [人类（*Homo sapiens*）PITX2基因：成对样同源域2](http://www.ncbi.nlm.nih.gov/gene/5308)
- [PITX2基因卡](http://www.genecards.org/cgi-bin/carddisp.pl?gene=PITX2&search=pitx2)
- [PITX2维基百科页面](http://en.wikipedia.org/wiki/PITX2)