WP5153 - N-glycan biosynthesis - Homo sapiens

This pathways describes the biosynthesis of N-linked (Asparagine-linked) glycans, to form glycoproteins. This process is a type of co-translational and post-translational modification and sometimes referred to as N-linked glycosylation. Glycosylation is important for many processes, including protein folding and cell-cell adhesion and immune function. This pathway was modeled based on Figure 9.3 and 9.4 from [Essentials of Glycobiology [Internet]. 3rd edition](https://www.ncbi.nlm.nih.gov/books/NBK453020/), Figure 17.1 from [Dall'Olio](https://link.springer.com/chapter/10.1007/978-981-13-2835-0_17) and [KEGG]9https://www.genome.jp/pathway/hsa005100.本通路旨在阐释N连接（天冬酰胺连接，Asparagine-linked）聚糖的生物合成过程，以制备糖蛋白（glycoproteins）。该过程属于共翻译与翻译后修饰的范畴，有时也被称为N连接糖基化（N-linked glycosylation）。糖基化对诸多生命过程具有关键作用，涵盖蛋白质折叠、细胞间黏附以及免疫功能调控。 本通路的建模参考了《糖生物学精要（第3版，网络版）》[Essentials of Glycobiology [Internet]. 3rd edition]中的图9.3与图9.4、[Dall'Olio]的图17.1，以及KEGG数据库的hsa005100通路（https://www.genome.jp/pathway/hsa005100）。