Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide

Kinetic stabilization of transthyretin through covalent modification of K15 by (E)-N-(4-(4-hydroxy-3,5-dimethylstyryl)phenyl)propionamide Descriptor: N-{4-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]phenyl}propanamide, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2012-10-14 Release date: 2013-12-04 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis. J.Am.Chem.Soc., 135, 2013通过(E)-N-(4-(4-羟基-3,5-二甲基苯乙烯基)苯基)丙酰胺对K15位点进行共价修饰，实现运甲状腺素蛋白（transthyretin）的动力学稳定。 描述符：N-{4-[(E)-2-(4-羟基-3,5-二甲基苯基)乙烯基]苯基}丙酰胺 靶标蛋白：运甲状腺素蛋白（transthyretin） 作者：Connelly, S、Wilson, I.A. 存档日期：2012-10-14 发布日期：2013-12-04 最后修改日期：2024-10-09 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.45埃 引用文献：二苯乙烯基乙烯磺酰胺类化合物：作为运甲状腺素蛋白的荧光传感器与无痕共价动力学稳定剂，可抑制淀粉样蛋白生成。《J. Am. Chem. Soc.》，135卷，2013年