Epigenomic Profiling of Primary Gastric Adenocarcinoma Reveals Super-enhancer Heterogeneity [methylation]

Regulatory elements in cancer remain poorly characterized in primary solid tumors. Here we applied microscale histone modification profiling to delineate the landscape of somatic promoters and super-enhancers in primary gastric adenocarcinoma, analyzing 94 epigenomic profiles of primary tumors, normal tissues, and cell lines DNA methylation profiles of 19 T/N pairs

实体瘤原发灶中的癌症调控元件仍缺乏充分的特征解析。本研究采用微尺度组蛋白修饰谱分析技术，对原发性胃腺癌的体细胞启动子与超级增强子（super-enhancers）调控全景进行系统解析；本次研究共分析了94份表观基因组谱，涵盖原发肿瘤、正常组织及细胞系样本，其中包含19对肿瘤-正常（T/N）配对样本的DNA甲基化谱。