Mus musculus strain:129S8 Epigenomics. Mus musculus strain:129S8

Genome-wide hyper-methylation is closely associated with abnormal expression of genes involved in neural development in induced pluripotent stem cells derived from a Down Syndrome mouse model在源自唐氏综合征小鼠模型（Down Syndrome mouse model）的诱导多能干细胞（induced pluripotent stem cells）中，全基因组高甲基化（Genome-wide hyper-methylation）与参与神经发育（neural development）的基因的异常表达密切相关。